This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with bovine, chimpanzee, mouse, rat and Xenopus based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Protein Kinase C theta of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and homeostasis. Transgenic mice over-expressing dominant negative PKC theta develop hyperinsulinimia. PKC theta is involved in JNK activation and also plays a specialized role in TCR-mediated activation of T and B cells. Through its control of Rap1, PKC theta establishes a threshold for T cell activation and positively regulates cytokine response and adhesive properties. The activation of PKC theta in T cells is associated with its recruitment to the membrane, and is mediated by PI3-kinase and Vav. PKC theta is a constitutively competent kinase and is phosphorylated on threonine 538 in the activation loop. The phosphorylation of threonine 538 is critical to PKC theta kinase activity, and plays an important role in PKC theta-mediated activation of nuclear factor kappaB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC126514; MGC141919; nPKC-theta; PRKCQ; PRKCT; Protein kinase C theta type; protein kinase C, theta; RP11-563J2.1
Gene Aliases: nPKC-theta; PRKCQ; PRKCT
UniProt ID: (Human) B4DF52
Entrez Gene ID: (Human) 5588
Molecular Function: annexin calcium-binding protein calmodulin intracellular calcium-sensing protein kinase non-receptor serine/threonine protein kinase protein kinase transfer/carrier protein transferase