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Invitrogen
Phospho-PKC zeta (Thr410) Monoclonal Antibody (S.447.6)
Product Details
MA5-15060
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
S.447.6
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding pThr410 of human PKC zeta
Conjugate
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_10983263
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The PKC family of serine/threonine kinases, including PRKCZ (PKC zeta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC zeta plays a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 14 - 3 - 3 - zeta isoform; atypical protein kinase C; kinase nPKC-zeta; KPCZ; nPKC-zeta; nPKC-zeta PRKCZ; protein kinase C zeta subspecies; Protein kinase C zeta type; protein kinase C, zeta
Gene Aliases: 14-3-3-zetaisoform; AI098070; aPKCzeta; C80388; nPKC-zeta; PKC-ZETA; PKC2; Pkcz; PRKCZ; r14-3-3; R74924; zetaPKC
UniProt ID: (Human) Q05513, (Rat) P09217, (Mouse) Q02956
Entrez Gene ID: (Human) 5590, (Rat) 25522, (Mouse) 18762
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein binding
ATP binding
potassium channel regulator activity
protein kinase binding
protein domain specific binding
phospholipase binding
insulin receptor substrate binding
metal ion binding
14-3-3 protein binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
microtubule cytoskeleton organization
positive regulation of cell-matrix adhesion
protein phosphorylation
inflammatory response
signal transduction
transforming growth factor beta receptor signaling pathway
long-term memory
positive regulation of cell proliferation
insulin receptor signaling pathway
cell migration
peptidyl-serine phosphorylation
establishment of cell polarity
negative regulation of protein complex assembly
actin cytoskeleton reorganization
activation of phospholipase D activity
activation of protein kinase B activity
positive regulation of interleukin-4 production
negative regulation of apoptotic process
positive regulation of T-helper 2 cell differentiation
positive regulation of glucose import
negative regulation of insulin receptor signaling pathway
positive regulation of insulin receptor signaling pathway
vesicle transport along microtubule
negative regulation of peptidyl-tyrosine phosphorylation
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
negative regulation of hydrolase activity
membrane depolarization
membrane hyperpolarization
long-term synaptic potentiation
positive regulation of ERK1 and ERK2 cascade
protein kinase C signaling
protein localization to plasma membrane
neuron projection extension
positive regulation of excitatory postsynaptic potential
positive regulation of T-helper 2 cell cytokine production
positive regulation of interleukin-5 secretion
positive regulation of interleukin-13 secretion
positive regulation of interleukin-10 secretion
cell surface receptor signaling pathway
cellular response to insulin stimulus
cellular protein localization
intracellular signal transduction
positive regulation of synaptic transmission
positive regulation of protein transport
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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