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|Tested species reactivity||Rat, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from human PKC zeta around the phosphorylation site of Threonine 410|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
14 - 3 - 3 - zeta isoform; atypical protein kinase C; EC 188.8.131.52; kinase PKC-zeta; KPCZ; nPKC-zeta; PKC-zeta; PKC2; PRKCZ; protein kinase C zeta subspecies; Protein kinase C zeta type
14-3-3-zetaisoform; AI098070; aPKCzeta; C80388; nPKC-zeta; PKC-ZETA; PKC2; Pkcz; r14-3-3; R74924; RP11-181G12.1; zetaPKC
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Intracellular signaling cascade Calcium mediated signaling Neuronal activities Apoptosis Induction of apoptosis Inhibition of apoptosis Cell proliferation and differentiation