Invitrogen
Antibody target was verified by Cell Treatment to ensure the antibody binds to the antigen stated. View details.
Catalog #:44-618G
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| TESTED APPLICATIONS | DILUTION |
|---|---|
| Immunocytochemistry (ICC) | 1:250 |
| Immunofluorescence (IF) | 1:250 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10-1:50 |
| Western Blot (WB) | Assay Dependent |
| PUBLISHED APPLICATIONS | |
|---|---|
| Western Blot (WB) | See 13 publications below |
| Miscellaneous PubMed (MISC) | See 3 publications below |
| Immunohistochemistry (IHC) | See 1 publications below |
| Immunofluorescence (IF) | See 1 publications below |
| Immunoprecipitation (IP) | See 2 publications below |
| Tested Species reactivity | Chicken, Human, Mouse, Rat |
| Published species reactivity | Tag , Rat , Human , Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human Pyk2 that contains tyrosine 402. The sequence is conserved in rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | Dulbecco's PBS, pH 7.3, with 50% glycerol, 1mg/ml BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| RRID | AB_2533697 |
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CADTK; CAK beta; CAK-beta; CAKB; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; cellular adhesion kinase beta; FADK 2; FADK2; Focal Adhesion Kinase 2; Proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; Protein-tyrosine kinase 2-beta; PTK; PTK2 protein tyrosine kinase 2 beta; PTK2B; PTK2B protein tyrosine kinase 2 beta; RAFTK; Related adhesion focal tyrosine kinase
Gene Aliases: CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK
UniProt ID: (Human) Q14289, (Mouse) Q9QVP9, (Rat) P70600
Entrez Gene ID: (Human) 2185, (Mouse) 19229, (Rat) 50646
Molecular Function:
kinase
non-receptor tyrosine protein kinase
protein kinase
transferase
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