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|Tested species reactivity||Human, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide corresponding to a portion of human Pyk 2 containing tyrosines 579 and 580. The sequence is conserved in human and rat.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.3, with 1mg/ml BSA, 50% glycerol|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.1-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-26674 detects PYK2 (phospho Y579 + Y580) from human and rat samples.
PA1-26674 has been successfully used in Western blot procedures. Suggested positive control is vandate treated CEF cells expressing PYK 2 and plated on fibronectin.
The PA1-26674 immunogen is a synthetic phosphopeptide corresponding to a portion of human Pyk 2 containing tyrosines 579 and 580. The sequence is conserved in human and rat.
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CADTK; CAK beta; CAK-beta; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; FADK; FADK 2; FAK; FAK1; focal adhesion kinase 2; FRNK; proline-rich tyrosine kinase 2; protein kinase B; protein-tyrosine kinase 2-beta; PTK2 protein tyrosine kinase 2 beta; PTK2B protein tyrosine kinase 2 beta; related adhesion focal tyrosine kinase
CADTK; CAKB; CAKbeta; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK