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7TM Antibodies
Phospho-Parathyroid Hormone Receptor 1 (Ser492, Ser493) Polyclonal Antibody
FIGURE: 1 / 1
Phospho-Parathyroid Hormone Receptor 1 (Ser492, Ser493) Antibody (7TM0331C) in WB
Agonist-induced Serine492/Serine493 phosphorylation of the Parathyroid Hormone Receptor 1. Upper panel, HEK293 cells stably expressing the Parathyroid Hormone receptor 1 (PTH1) were either not exposed or exposed to 100 nM PTH for 30 minutes. Cells were lysed and immunoblotted with the anti-pS492/pS493-PTH1 antibody (7TM0331C) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed with the pho... View More
Product Details
7TM0331C
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human PTH1 around the phosphorylation site of Ser492/Ser493.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Parathyroid hormone receptor 1 is a member of the G-protein coupled receptor family. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Parathyroid hormone receptor 1 has been reported to be expressed in bone, breast, brain, colon, GI, kidney, liver, placenta, skin, umbilical cord, and uterus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC138426; MGC138452; Parathormone; Parathyrin; Parathyroid hormone 1 receptor; parathyroid hormone receptor; parathyroid hormone receptor 1; Parathyroid hormone/parathyroid hormone-related peptide receptor; parathyroid hormone/parathyroid hormone-related protein receptor; PTH; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; PTHrP-R; PTHrP-receptor; seven transmembrane helix receptor
Gene Aliases: PFE; PTH1R; PTHR; PTHR1
UniProt ID: (Human) Q03431
Entrez Gene ID: (Human) 5745
skeletal system development
chondrocyte differentiation
osteoblast development
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
aging
positive regulation of cell proliferation
negative regulation of cell proliferation
bone mineralization
bone resorption
cell maturation
positive regulation of inositol phosphate biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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