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|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human PLC-gamma-1 that contains tyrosine 783. This region is conserved among many species including mouse, rat, cow and frog.|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.3, with 50% glycerol, 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Human||1:1000||Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo.||Tugues S,Honjo S,König C,Padhan N,Kroon J,Gualandi L,Li X,Barkefors I,Thijssen VL,Griffioen AW,Claesson-Welsh L||The Journal of biological chemistry (288:19060)||2013|
|Mouse||Not Cited||Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.||Zikherman J,Doan K,Parameswaran R,Raschke W,Weiss A||Proceedings of the National Academy of Sciences of the United States of America (109:E3)||2012|
|Human||Not Cited||Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.||Deindl S,Kadlecek TA,Cao X,Kuriyan J,Weiss A||Proceedings of the National Academy of Sciences of the United States of America (106:20699)||2009|
|Human||Not Cited||Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.||Brdicka T,Kadlecek TA,Roose JP,Pastuszak AW,Weiss A||Molecular and cellular biology (25:4924)||2005|
|Human||Not Cited||Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis.||Arbiser JL,Govindarajan B,Bai X,Onda H,Kazlauskas A,Lim SD,Amin MB,Claesson-Welsh L||The American journal of pathology (161:781)||2002|
||Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.||Zikherman J,Doan K,Parameswaran R,Raschke W,Weiss A||Proceedings of the National Academy of Sciences of the United States of America (109:E3)||2012|
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 1-phosphatidylinositol-4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; 5-bisphosphate phosphodiesterase gamma 1; cell differentiation and embryonic development; EC 22.214.171.124; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-148; Phospholipase C-gamma-1; Phospholipase C-II; PLC-148; PLC-gamma-1; PLC-gamma1; PLC-II; PLC1; PLCG-1; triphosphoinositide phosphodiesterase
AI894140; Cded; NCKAP3; Plc-1; Plc-gamma1; PLC-II; PLC1; PLC148; Plcg-1; PLCG1; PLCgamma1