PA5-34970 targets Phospho-RAD17 pSer646 in WB applications and shows reactivity with Human samples.
The PA5-34970 immunogen is synthetic peptide contains a sequence corresponding to a region within amino acids 592 and 681 of Rad17 (phospho Ser646).
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cell cycle checkpoint protein (RAD17); cell cycle checkpoint protein RAD17; RAD1 homolog; Rad17-like protein; RF-C activator 1 homolog; RF-C/activator 1 homolog
Gene Aliases: CCYC; HRAD17; R24L; RAD17SP; RAD24
UniProt ID: (Human) O75943
Entrez Gene ID: (Human) 5884