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|Tested species reactivity||Human, Yeast|
|Host / Isotype||Mouse / IgM|
|Immunogen||Synthetic peptide: YSPTSpPS (Human) from Sp2/0 Ag.14 cells|
|Contains||0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-5875 detects Phospho-RNA polymerase II CTD in human and S. cerevisiae samples.
MA1-5875 has been successfully used in Western blot, ELISA and immunofluorescence procedures.
The MA1-5875 immunogen is synthetic peptide, YSPTSpPS (human).
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; Pol2p; polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; polymerase (RNA) II subunit A; RNA Pol2; RNA polymerase II subunit B1; RNA-directed RNA polymerase II subunit RPB1
DUN2; hRPB220; hsRPB1; N0825; POL2; POLR2; POLR2A; POLRA; RPB1; RPBh1; RpIILS; RPO2; RPOL2; YNL262W