|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide derived from human ROS around the phosphorylation site of Tyrosine 2114|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody detects endogenous protein at a molecular weight of 264 kDa.
Purity is >95% by SDS-PAGE.
LTK, ALK and Ros have been identified as receptor tyrosine kinases having sequence similarity to the insulin receptor subfamily of kinases. LTK, leukocyte tyrosine kinase, is expressed in murine B-lymphocyte precursors and has also been found in forebrain neurons. ALK, anaplastic lymphoma kinase, is normally highly expressed specifically in the nervous system. A truncated form containing the catalytic domian of ALK is expressed as the result of a translocation occuring in many non-Hodgkin's lymphomas. The c-ros gene was originally identified in mutant form as an oncogene. Ros is normally expressed in a small number of epithelial cell types and may play a role in epithelial development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-ros oncogene 1 , receptor tyrosine kinase; c-Ros receptor tyrosine kinase; c-ros-1; heart - derived c - ros - 1 proto - oncogene; MCF3; Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Proto-oncogene tyrosine-protein kinase ROS; Receptor tyrosine kinase c-ros oncogene 1; ROS; ROS proto-oncogene 1 , receptor tyrosine kinase; ROS1; Ros1 proto-oncogene; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1
Gene Aliases: c-ros; c-ros-1; MCF3; ROS; Ros-1; ROS1; ROS1C
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