Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: RNA polymerase I-specific transcription initiation factor RRN3; RRN3 RNA polymerase I transcription factor homolog; TIF-IA; Transcription initiation factor IA; transcription initiation factor TIF-IA
Gene Aliases: A-270G1.2; RRN3; TIFIA
UniProt ID: (Human) Q9NYV6
Entrez Gene ID: (Human) 54700
Molecular Function: general transcription factor