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Invitrogen
Phospho-RSK1/RSK2 (Ser221, Ser227) Polyclonal Antibody
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Product Details
PA5-149486
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Phosphopeptide containing human RSK1 S221 site
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
RSK1 (Ribosomal S6 Kinase 1) and RSK2 (Ribosomal S6 Kinase 2) are genes that encode members of the RSK family of serine/threonine kinases, which are downstream effectors of the extracellular signal-regulated kinase (ERK) signaling pathway. These kinases play critical roles in regulating various cellular processes, including growth, proliferation, survival, and differentiation. RSK1 and RSK2 are activated by phosphorylation in response to extracellular signals such as growth factors, hormones, and mitogens. Once activated, they phosphorylate a range of substrates, including transcription factors, ribosomal proteins, and other kinases, thereby influencing gene expression and protein synthesis. Dysregulation of RSK1 and RSK2 activity has been implicated in several pathological conditions, including cancer, where they can promote tumor growth and survival, and neurodevelopmental disorders, such as Coffin-Lowry syndrome, which is associated with mutations in the RSK2 gene. Understanding the function and regulation of RSK1 and RSK2 is essential for developing targeted therapies aimed at modulating their activity in disease contexts. Research into these kinases provides valuable insights into the broader mechanisms of ERK signaling and its impact on cellular physiology and disease progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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