The p90 ribosomal S6 kinases (RSK)1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin-Lowry syndrome, which is characterized by mental retardation and growth deficits (Hanauer and Young, 2002). Recent work suggests that RSK2 exerts a tonic regulation on G-protein coupled signaling (Sheffler et al., 2006).
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Protein Aliases: 90 kDa ribosomal protein S6 kinase 2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1C; MAPKAPK-1c; mitogen-activated protein kinase-activated protein kinase 1C; p90-RSK 2; p90RSK2; pp90RSK3; Protein-tyrosine kinase Mpk-9; ribosomal protein S6 kinase alpha 2; Ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase, 90kD, polypeptide 2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; Ribosomal S6 kinase 3; RSK-3; S6K-alpha 2; S6K-alpha-2
Gene Aliases: 90kDa; D17Wsu134e; HU-2; MAPKAPK1C; p90-RSK3; p90rsk; p90RSK2; pp90rsk; pp90RSK3; Rps6ka-rs1; RPS6KA2; RSK; RSK3; S6K-alpha; S6K-alpha2