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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from human AML1 around the phosphorylation site of Serine 276|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B- dependent transcriptional activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
acute myeloid leukemia 1 protein; AML1-EVI-1 fusion protein; CBF-alpha 2; CBF-alpha-2; CBFA2; core binding factor alpha 2; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); core-binding factor subunit alpha-2; Core-binding factor, alpha 2 subunit; core-binding factor, runt domain, alpha subunit 2; oncogene AML-1; PEA2-alpha B; PEBP2-alpha B; Polyomavirus enhancer binding protein 2 alpha B subunit; polyomavirus enhancer-binding protein 2 alpha B subunit; RUN1; runt domain, alpha subunit 2; runt related transcription factor 1; Runt-related transcription factor 1; RUNX1; SL3-3 enhan; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit
AML1; AML1-EVI-1; AMLCR1; CBF-alpha-2; CBFA2; EVI-1; Pebp2a2; PEBP2aB; Pebpa2b
Nucleoside, nucleotide and nucleic acid metabolism mRNA transcription mRNA transcription regulation Signal transduction Oncogenesis Oncogene Developmental processes Embryogenesis Ectoderm development Neurogenesis Mesoderm development Skeletal development Hematopoiesis Sex determination Cell proliferation and differentiation