|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic phosphopeptide derived from human Rabphilin 3A around the phosphorylation site of Ser237 (R-A-SP-E-A)|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
Rabphilin 3A, a target protein for the small GTPase binding protein rab 3A, plays a role in regulated secretion, particularly in neurotransmitter release. Double labeling of rab 3A and rabphilin 3A shows the two proteins to be co-localized in nerve terminals of the spinal cord and motor endplates. Rabphilin binds selectively to the GTP bound form of rab 3A as well as of rab 3c. Studies suggest that rabphilin 3A phosphorylation by CaM kinase II modulates neurotransmitter release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Exophilin-1; rabphilin 3A homolog; rabphilin 3A homolog mouse; Rabphilin-3A; RPH3A
Gene Aliases: 2900002P20Rik; AU022689; AW108370; KIAA0985; RPH3A
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