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|Tested species reactivity||Human|
|Host / Isotype||Rat / IgG1|
|Immunogen||A synthetic peptide corresponding to aa GQRDSSYYWEIEAS|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||2-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-14603 targets Phospho-Raf-1 pY341/S339 in IHC (P) applications and shows reactivity with Human samples.
The MA5-14603 immunogen is a synthetic peptide corresponding to aa GQRDSSYYWEIEAS.
Raf1 is an important mediator of signal transduction pathway. It is activated through activation by Src and protein kinase C. It further phosphorylates Mek1 and cdc25. It can bind to GTP-bound Ras through N-terminal domain. It also interacts with hsp90 and 14.3.3 family of proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
C-Raf proto-oncogene, serine/threonine kinase; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1
c-Raf; CMD1NN; CRAF; NS5; RAF; Raf-1; RAF1