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Invitrogen
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:10-1:50 | - |
Immunohistochemistry (IHC) |
- | View 1 publication 1 publication |
Product Specifications | |
---|---|
Species Reactivity |
Human |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human SGK1 that contains serine 422. |
Conjugate |
Unconjugated |
Form |
Liquid |
Purification |
Affinity chromatography |
Storage buffer |
Dulbecco's PBS, pH 7.3, with 1mg/mL BSA, 50% glycerol |
Contains |
0.05% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2533593 |
Serum and glucocorticoid-regulated protein kinase 1 (SGK1) is a member of the AGC family of serine/threonine kinases that plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. SGK1 functions as a regulator of cell survival and ion channels and transporters such as ENaC or KCNA3/Kv1. 3. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: serine/threonine protein kinase SGK; Serine/threonine-protein kinase Sgk1; Serum/glucocorticoid-regulated kinase 1; Sgk1 variant i3
Gene Aliases: SGK; SGK1
UniProt ID: (Human) B7UUP7
Entrez Gene ID: (Human) 6446
Molecular Function:
protein modifying enzyme
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