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Product Details
19561-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Acetyltransferase SPHK1; RP23-193A16.4; SK 1; SKase; Sphingosine kinase 1; SPK 1
Gene Aliases: SK1; SPHK; SPHK1; SPK
UniProt ID: (Human) Q9NYA1
Entrez Gene ID: (Human) 8877
blood vessel development
positive regulation of neurotransmitter secretion
sphingosine-1-phosphate signaling pathway
protein folding
sphingosine metabolic process
inflammatory response
signal transduction
brain development
female pregnancy
cellular response to starvation
positive regulation of peptidyl-threonine phosphorylation
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of neuron projection development
response to amine
cyclooxygenase pathway
calcium-mediated signaling
sphingolipid biosynthetic process
positive regulation of cell growth
positive regulation of cell migration
positive regulation of protein ubiquitination
response to magnesium ion
response to progesterone
regulation of interleukin-1 beta production
response to ATP
intracellular signal transduction
positive regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
positive regulation of angiogenesis
positive regulation of mitotic cell cycle
positive regulation of smooth muscle contraction
sphingosine biosynthetic process
sphingoid catabolic process
lipid phosphorylation
positive regulation of fibroblast proliferation
positive regulation of NF-kappaB transcription factor activity
cellular response to hydrogen peroxide
response to interleukin-1
cellular response to growth factor stimulus
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