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|Tested species reactivity||Chicken, Human, Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||This antibody was produced against a chemically synthesized phosphopeptide derived from the region of Src that contains tyrosine 418. The antibody was affinity purified by sequential epitope-specific chromatography, then conjugated to Alexa FluorÒ 488 under optimal conditions.|
|Conjugate||Alexa Fluor® 488|
|Storage buffer||Dulbecco's PBS, pH 7.3, with 0.2mg/ml BSA|
|Contains||0.05% sodium azide|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. Transcript Variant: This variant (1) represents the longer transcript. Both isoforms 1 and 2 encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.
44-660A1 was used in western blot to determine the role and mechanism of focal adhesion kinase-mediated signaling in mammary gland development and differentiation.
|van Miltenburg MH,Lalai R,de Bont H,van Waaij E,Beggs H,Danen EH,van de Water B||FASEB journal : official publication of the Federation of American Societies for Experimental Biology (23:3482)||2009|
c-Src; EC 126.96.36.199; neuronal proto-oncogene tyrosine-protein kinase Src; non-tyrosine protein kinase; p60-Src; pp60c-src; proto-oncogene c-Src; proto-oncogene tyrosine-protein kinase Src; protooncogene SRC, Rous sarcoma; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
ASV; AW259666; c-SRC; p60-Src; PP60C-SCR; pp60c-src; SDR; SRC; SRC1; THC6