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Invitrogen

Phospho-SRC1 (Thr1179) Polyclonal Antibody

View all (15) SRC1 antibodies
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Product Details

Applications
Tested Dilution
Publications
Western Blot (WB)
1:1000
-
Product Specifications
Species Reactivity
Human, Mouse
Host / Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SRC-1 (Phospho-Thr1179)
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
RRID
AB_2663075

Product Specific Information

Phospho-SRC1 (Thr1179) Polyclonal Antibody detects endogenous levels of SRC1 only when phosphorylated at Thr1179.

Target Information

Clone 1135 recognizes SRC-1, steroid-receptor coactivator-1. SRC-1 is a member of a gene family that functions in the full transcriptional activation of the steroid hormone receptor superfamily and contains intrinsic histone acetyltransferase activity. SRC-1 has a molecular weight of 160 kDa and has a basic helix-loop-helix (bHLH)-PAS domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ASV; bHLHe74; c-SRC; Class E basic helix-loop-helix protein 74; Hin-2 protein; mNRC-1; NCoA-1; Nuclear receptor coactivator 1; Nuclear receptor coactivator protein 1; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160; SRC-1; SRC-1 (-Q); SRC-a/NCoA-1; Steroid receptor coactivator 1; steroid receptor coactivator-1

Gene Aliases: bHLHe42; BHLHE74; F-SRC-1; KAT13A; NCOA1; RIP160; SRC-1; SRC1

UniProt ID: (Human) Q15788, (Mouse) P70365

Entrez Gene ID: (Human) 8648, (Mouse) 17977

Molecular Function: acetyltransferase transcription factor transferase

Function(s)
positive regulation of transcription from RNA polymerase II promoter by galactose regulation of thyroid hormone mediated signaling pathway transcription, DNA-templated lactation male gonad development bile acid and bile salt transport cerebellum development hippocampus development hypothalamus development cerebral cortex development androgen receptor signaling pathway intracellular receptor signaling pathway response to estradiol response to retinoic acid response to progesterone cellular response to hormone stimulus positive regulation of apoptotic process histone H4 acetylation cellular lipid metabolic process estrous cycle positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter male mating behavior labyrinthine layer morphogenesis cellular response to Thyroglobulin triiodothyronine regulation of cellular response to drug regulation of transcription, DNA-templated signal transduction regulation of nucleic acid-templated transcription regulation of RNA biosynthetic process
Process(es)
RNA polymerase II regulatory region DNA binding RNA polymerase II transcription coactivator activity chromatin binding transcription coactivator activity histone acetyltransferase activity protein binding ligand-dependent nuclear receptor binding enzyme binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity protein complex binding progesterone receptor binding nuclear hormone receptor binding retinoid X receptor binding protein dimerization activity protein N-terminus binding androgen receptor binding DNA binding signal transducer activity transcription factor binding transferase activity transferase activity, transferring acyl groups retinoic acid receptor binding

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