Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF-binding sites are also constitutive promotor elements in many muscle-specific promotors. At the c-Fos SRE, formation of a ternary complex containing SRF and its accessory protein p62TCF appears to be important for signal transduction. Two related Ets domain proteins, Elk-1 and SRF accessory protein-1 (SAP-1) have DNA binding properties identical to that of p62TCF. Elk-1 and SAP-1 contain two homologous regions of which the two amino-terminal regions, the Ets domain (box A) and the B box, mediate ternary complex formation with SRF.
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Protein Aliases: C-FOS SERUM RESPONSE ELEMENT-BINDING FACTOR; c-fos serum response element-binding transcription factor; minichromosome maintenance 1 homolog; Serum response factor; serum response factor (c-fos serum response element-binding transcription factor); SRF
Gene Aliases: AW049942; AW240594; MCM1; RGD1559787; SRF