Phospho-STAT4 (Ser721) Polyclonal Antibody detects endogenous levels of STAT4 only when phosphorylated at Ser721.
The STAT 4 protein is a transcription factor activated by hormone and cytokines. STAT 4 is most similar to STAT 1 (52%) and STAT 3 (47%). Functionally, STAT 4 is similar to other STAT family members in that it can be tyrosine phosphorylated by JAK 1 or JAK 2. STAT 4 forms homodimers and heterodimers with related STAT family members. Tyrosine phosphorylated STAT 4 can bind the interferon g activated site (GAS), and serine phosphorylation is also required for maximal transcriptional activity. STAT 4 expression is restricted to the thymus, spleen, and testis.
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Protein Aliases: CIS4; HSPC060; Signal Transducer and Activator of Transcription; Signal transducer and activator of transcription 4; SOCS4; SOCS6; SSI4; STAI4; STATI4
Gene Aliases: SLEB11; STAT4