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Product Details
PA5-121312
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphorylated peptide around Y694 of human STAT5 (NP_003143.2/NP_036580.2).
Conjugate
Unconjugated
Form
Liquid
Concentration
2.38 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2914884
Product Specific Information
Positive test controls include: K562.
Target Information
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mammary gland factor; mammary gland factor STAT5A; mammary gland factor STAT5B; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5B; STA5B; STAT; transcription factor STAT5B
Gene Aliases: AA959963; MGF; Mpf; STAT5; STAT5A; STAT5B
UniProt ID: (Human) P42229, (Human) P51692, (Rat) Q62771, (Mouse) P42230, (Rat) P52632, (Mouse) P42232
Entrez Gene ID: (Human) 6776, (Human) 6777, (Rat) 24918, (Mouse) 20850, (Rat) 25126, (Mouse) 20851
Molecular Function:
DNA-binding transcription factor
allantoin metabolic process
positive regulation of endothelial cell proliferation
citrate metabolic process
2-oxoglutarate metabolic process
succinate metabolic process
oxaloacetate metabolic process
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
isoleucine metabolic process
valine metabolic process
creatine metabolic process
fatty acid metabolic process
JAK-STAT cascade
lactation
peptidyl-tyrosine phosphorylation
taurine metabolic process
prolactin signaling pathway
regulation of multicellular organism growth
positive regulation of blood vessel endothelial cell migration
creatinine metabolic process
JAK-STAT cascade involved in growth hormone signaling pathway
luteinization
response to hypoxia
natural killer cell differentiation
liver development
transcription from RNA polymerase II promoter
acute-phase response
female pregnancy
regulation of steroid metabolic process
lipid storage
regulation of epithelial cell differentiation
response to estradiol
response to lipopolysaccharide
positive regulation of natural killer cell proliferation
positive regulation of natural killer cell differentiation
cellular response to hormone stimulus
T cell differentiation in thymus
positive regulation of multicellular organism growth
positive regulation of activated T cell proliferation
progesterone metabolic process
T cell homeostasis
negative regulation of apoptotic process
positive regulation of interleukin-2 biosynthetic process
response to ethanol
positive regulation of B cell differentiation
positive regulation of gamma-delta T cell differentiation
negative regulation of erythrocyte differentiation
positive regulation of erythrocyte differentiation
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of natural killer cell mediated cytotoxicity
development of secondary female sexual characteristics
development of secondary male sexual characteristics
Peyer's patch development
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
positive regulation of cellular component movement
response to interleukin-2
response to interleukin-4
response to interleukin-15
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
mast cell migration
regulation of transcription, DNA-templated
signal transduction
positive regulation of cell proliferation
cytokine-mediated signaling pathway
regulation of cell adhesion
mammary gland development
response to nutrient levels
negative regulation of mast cell apoptotic process
response to peptide hormone
positive regulation of lymphocyte differentiation
multicellular organismal reproductive process
mammary gland involution
positive regulation of mast cell differentiation
prostate gland epithelium morphogenesis
epithelial cell differentiation involved in prostate gland development
mammary gland epithelium development
positive regulation of mast cell proliferation
cellular response to granulocyte macrophage colony-stimulating factor stimulus
sex differentiation
DNA binding
transcription factor activity, sequence-specific DNA binding
protein tyrosine kinase activity
signal transducer activity
protein binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
protein phosphatase binding
glucocorticoid receptor binding
protein dimerization activity
double-stranded DNA binding
sequence-specific DNA binding
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