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Invitrogen
Phospho-TAB2 (Ser450) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-TAB2 (Ser450) Antibody (PA5-105086) in WB
Western blot analysis of Phospho-TAB2 (Ser450) in 293T cell lysate (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-TAB2 (Ser450) polyclonal antibody (Product # PA5-105086).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105086
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TAB2(Accession Q9NYJ8), corresponding to amino acid residues around phosphorylated Ser450.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of TAB2 only when phosphorylated at Ser450.
Target Information
TAB2 is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutively interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ21885; MAP3K7IP2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2; OTTHUMP00000017388; TAB2; Tak1 binding protein 2; TAK1-binding protein 2; TGF-beta-activated kinase 1-binding protein 2; unnamed protein product
Gene Aliases: 1110030N06Rik; A530078N03Rik; CHTD2; MAP3K7IP2; mKIAA0733; TAB-2
UniProt ID: (Human) Q9NYJ8, (Mouse) Q99K90
Entrez Gene ID: (Human) 23118, (Mouse) 68652
inflammatory response
I-kappaB kinase/NF-kappaB signaling
heart development
response to lipopolysaccharide
NIK/NF-kappaB signaling
p38MAPK cascade
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of MAPK cascade
positive regulation of protein kinase activity
protein K63-linked ubiquitination
response to bacterium
negative regulation of autophagy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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