Product References
C9orf72 poly(PR) aggregation in nucleus induces ALS/FTD-related neurodegeneration in cynomolgus monkeys.
Neurobiology of disease
Xu L,Wang D,Zhao L,Yang Z,Liu X,Li X,Yuan T,Wang Y,Huang T,Bian N,He Y,Chen X,Tian B,Liu Z,Luo F,Si W,Gao G,Ji W,Niu Y,Wei J
Tue Aug 01 00:00:00 EDT 2023
TDP-43 and tau concurrence in the entorhinal subfields in primary age-related tauopathy and preclinical Alzheimer's disease.
Brain pathology (Zurich, Switzerland)
Llamas-Rodríguez J,Oltmer J,Marshall M,Champion S,Frosch MP,Augustinack JC
Sat Jul 01 00:00:00 EDT 2023
Looking for answers far away from the soma-the (un)known axonal functions of TDP-43, and their contribution to early NMJ disruption in ALS.
Molecular neurodegeneration
Ionescu A,Altman T,Perlson E
Wed May 31 00:00:00 EDT 2023
Looking for answers far away from the soma-the (un)known axonal functions of TDP-43, and their contribution to early NMJ disruption in ALS.
Molecular neurodegeneration
Ionescu A,Altman T,Perlson E
Wed May 31 00:00:00 EDT 2023
Design and application of a customizable relational DataBase to assess clinicopathological correlations and concomitant pathology in neurodegenerative diseases.
Brain pathology (Zurich, Switzerland)
Journe-Mallet I,Gouju J,Etcharry-Bouyx F,Chauvire V,Guillet-Pichon V,Scherer-Gagou C,Prundean A,Godard S,Lecluse A,Cassereau J,Verny C,Letournel F,Codron P
Mon May 01 00:00:00 EDT 2023
Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations.
Acta neuropathologica communications
Davis SE,Cook AK,Hall JA,Voskobiynyk Y,Carullo NV,Boyle NR,Hakim AR,Anderson KM,Hobdy KP,Pugh DA,Murchison CF,McMeekin LJ,Simmons M,Margolies KA,Cowell RM,Nana AL,Spina S,Grinberg LT,Miller BL,Seeley WW,Arrant AE
Fri Apr 28 00:00:00 EDT 2023
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis.
Scientific reports
Bashore FM,Marquez AB,Chaikuad A,Howell S,Dunn AS,Beltran AA,Smith JL,Drewry DH,Beltran AS,Axtman AD
Fri Apr 14 00:00:00 EDT 2023
Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behaviors.
Human molecular genetics
Ma L,Liang C,Wang J,Chang Q,Wang Y,Zhang W,Du Y,Sadan J,Chen JF
Thu Apr 06 00:00:00 EDT 2023
Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.
ASN neuro
Ohene-Nyako M,Nass SR,Richard HT,Lukande R,Nicol MR,McRae M,Knapp PE,Hauser KF
Fri Mar 10 00:00:00 EST 2023
Endogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration.
Nature communications
Chang YH,Dubnau J
Tue Feb 21 00:00:00 EST 2023
Endogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration.
Nature communications
Chang YH,Dubnau J
Tue Feb 21 00:00:00 EST 2023
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Cell
Hung ST,Linares GR,Chang WH,Eoh Y,Krishnan G,Mendonca S,Hong S,Shi Y,Santana M,Kueth C,Macklin-Isquierdo S,Perry S,Duhaime S,Maios C,Chang J,Perez J,Couto A,Lai J,Li Y,Alworth SV,Hendricks E,Wang Y,Zlokovic BV,Dickman DK,Parker JA,Zarnescu DC,Gao FB,Ichida JK
Thu Feb 16 00:00:00 EST 2023
Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders.
Nature communications
Cui Y,Arnold FJ,Peng F,Wang D,Li JS,Michels S,Wagner EJ,La Spada AR,Li W
Fri Feb 03 00:00:00 EST 2023
SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS.
Cell stem cell
Linares GR,Li Y,Chang WH,Rubin-Sigler J,Mendonca S,Hong S,Eoh Y,Guo W,Huang YH,Chang J,Tu S,Dorjsuren N,Santana M,Hung ST,Yu J,Perez J,Chickering M,Cheng TY,Huang CC,Lee SJ,Deng HJ,Bach KT,Gray K,Subramanyam V,Rosenfeld J,Alworth SV,Goodarzi H,Ichida JK
Thu Feb 02 00:00:00 EST 2023
Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts.
International journal of molecular sciences
Porras G,Ruiz S,Maestro I,Borrego-Hernández D,Redondo AG,Martínez A,Martín-Requero Á
Thu Feb 02 00:00:00 EST 2023
Neuropathology of spinocerebellar ataxia type 8: Common features and unique tauopathy.
Neuropathology : official journal of the Japanese Society of Neuropathology
Yonenobu Y,Beck G,Kido K,Maeda N,Yamashita R,Inoue K,Saito Y,Hasegawa M,Ito H,Hasegawa K,Morii E,Iwaki T,Murayama S,Mochizuki H
Thu Jan 26 00:00:00 EST 2023
Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP.
Brain pathology (Zurich, Switzerland)
Cooper-Knock J,Julian TH,Feneberg E,Highley JR,Sidra M,Turner MR,Talbot K,Ansorge O,Allen SP,Moll T,Shelkovnikova T,Castelli L,Hautbergue GM,Hewitt C,Kirby J,Wharton SB,Mead RJ,Shaw PJ
Sun Jan 01 00:00:00 EST 2023
Therapeutic Effect of Rapamycin on TDP-43-Related Pathogenesis in Ischemic Stroke.
International journal of molecular sciences
Tsou YS,Lai JH,Chen KY,Chang CF,Huang CC
Fri Dec 30 00:00:00 EST 2022
Apolipoprotein L1 is increased in frontotemporal lobar degeneration post-mortem brain but not in ante-mortem cerebrospinal fluid.
Neurobiology of disease
Hok-A-Hin YS,Dijkstra AA,Rábano A,Hoozemans JJ,Castillo L,Seelaar H,van Swieten JC,Pijnenburg YAL,Teunissen CE,Del Campo M
Sat Oct 01 00:00:00 EDT 2022
DNAJB2-related Charcot-Marie-Tooth disease type 2: Pathomechanism insights and phenotypic spectrum widening.
European journal of neurology
Saveri P,Magri S,Maderna E,Balistreri F,Lombardi R,Ciano C,Moda F,Garavaglia B,Reale C,Lauria Pinter G,Taroni F,Pareyson D,Pisciotta C
Fri Jul 01 00:00:00 EDT 2022
TDP-43 Accumulation Within Intramuscular Nerve Bundles of Patients With Amyotrophic Lateral Sclerosis.
JAMA neurology
Kurashige T,Morino H,Murao T,Izumi Y,Sugiura T,Kuraoka K,Kawakami H,Torii T,Maruyama H
Fri Jul 01 00:00:00 EDT 2022
TDP-43 Accumulation Within Intramuscular Nerve Bundles of Patients With Amyotrophic Lateral Sclerosis.
JAMA neurology
Kurashige T,Morino H,Murao T,Izumi Y,Sugiura T,Kuraoka K,Kawakami H,Torii T,Maruyama H
Fri Jul 01 00:00:00 EDT 2022
Clinico-pathological comparison of patients with autopsy-confirmed Alzheimer's disease, dementia with Lewy bodies, and mixed pathology.
Alzheimer's & dementia (Amsterdam, Netherlands)
Chatterjee A,Hirsch-Reinshagen V,Moussavi SA,Ducharme B,Mackenzie IR,Hsiung GR
Sat Apr 23 00:00:00 EDT 2022
An autopsy case of Alzheimer's disease with amygdala-predominant Lewy pathology presenting with frontotemporal dementia-like psychiatric symptoms.
Neuropathology : official journal of the Japanese Society of Neuropathology
Beck G,Shigenobu K,Ukon K,Yamashita R,Yonenobu Y,Morii E,Hasegawa M,Ikeda M,Murayama S,Mochizuki H
Fri Apr 01 00:00:00 EDT 2022
An open source toolkit for repurposing Illumina sequencing systems as versatile fluidics and imaging platforms.
Scientific reports
Pandit K,Petrescu J,Cuevas M,Stephenson W,Smibert P,Phatnani H,Maniatis S
Thu Mar 24 00:00:00 EDT 2022
TDP-43 Pathology and Prionic Behavior in Human Cellular Models of Alzheimer's Disease Patients.
Biomedicines
Cuevas EP,Rodríguez-Fernández A,Palomo V,Martínez A,Martín-Requero Á
Sat Feb 05 00:00:00 EST 2022
TDP-43 Pathology and Prionic Behavior in Human Cellular Models of Alzheimer's Disease Patients.
Biomedicines
Cuevas EP,Rodríguez-Fernández A,Palomo V,Martínez A,Martín-Requero Á
Sat Feb 05 00:00:00 EST 2022
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.
Nature neuroscience
Xie M,Liu YU,Zhao S,Zhang L,Bosco DB,Pang YP,Zhong J,Sheth U,Martens YA,Zhao N,Liu CC,Zhuang Y,Wang L,Dickson DW,Mattson MP,Bu G,Wu LJ
Sat Jan 01 00:00:00 EST 2022
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.
Nature neuroscience
Xie M,Liu YU,Zhao S,Zhang L,Bosco DB,Pang YP,Zhong J,Sheth U,Martens YA,Zhao N,Liu CC,Zhuang Y,Wang L,Dickson DW,Mattson MP,Bu G,Wu LJ
Sat Jan 01 00:00:00 EST 2022
Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins.
Nature communications
Altman T,Ionescu A,Ibraheem A,Priesmann D,Gradus-Pery T,Farberov L,Alexandra G,Shelestovich N,Dafinca R,Shomron N,Rage F,Talbot K,Ward ME,Dori A,Krüger M,Perlson E
Thu Nov 25 00:00:00 EST 2021
Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins.
Nature communications
Altman T,Ionescu A,Ibraheem A,Priesmann D,Gradus-Pery T,Farberov L,Alexandra G,Shelestovich N,Dafinca R,Shomron N,Rage F,Talbot K,Ward ME,Dori A,Krüger M,Perlson E
Thu Nov 25 00:00:00 EST 2021
Fast Progression in Amyotrophic Lateral Sclerosis Is Associated With Greater TDP-43 Burden in Spinal Cord.
Journal of neuropathology and experimental neurology
Cathcart SJ,Appel SH,Peterson LE,Greene EP,Powell SZ,Arumanayagam AS,Rivera AL,Cykowski MD
Fri Sep 10 00:00:00 EDT 2021
Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis.
International journal of molecular sciences
Martínez-González L,Gonzalo-Consuegra C,Gómez-Almería M,Porras G,de Lago E,Martín-Requero Á,Martínez A
Fri Aug 20 00:00:00 EDT 2021
Amyotrophic lateral sclerosis with speech apraxia, predominant upper motor neuron signs, and prominent iron accumulation in the frontal operculum and precentral gyrus.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mitani TT,Beck G,Kido K,Yamashita R,Yonenobu Y,Ogawa T,Saeki C,Okuno T,Nagano S,Morii E,Hasegawa M,Saito Y,Murayama S,Mochizuki H
Sun Aug 01 00:00:00 EDT 2021
Detection and quantification of novel C-terminal TDP-43 fragments in ALS-TDP.
Brain pathology (Zurich, Switzerland)
Feneberg E,Charles PD,Finelli MJ,Scott C,Kessler BM,Fischer R,Ansorge O,Gray E,Talbot K,Turner MR
Thu Jul 01 00:00:00 EDT 2021
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.
Acta neuropathologica communications
Kahriman A,Bouley J,Smith TW,Bosco DA,Woerman AL,Henninger N
Tue Jun 29 00:00:00 EDT 2021
Neuroinflammation is highest in areas of disease progression in semantic dementia.
Brain : a journal of neurology
Pascual B,Funk Q,Zanotti-Fregonara P,Cykowski MD,Veronese M,Rockers E,Bradbury K,Yu M,Nakawah MO,Román GC,Schulz PE,Arumanayagam AS,Beers D,Faridar A,Fujita M,Appel SH,Masdeu JC
Tue Jun 22 00:00:00 EDT 2021
CdSe Quantum Dots in Human Models Derived from ALS Patients: Characterization, Nuclear Penetration Studies and Multiplexing.
Nanomaterials (Basel, Switzerland)
Tosat-Bitrián C,Avis-Bodas A,Porras G,Borrego-Hernández D,García-Redondo A,Martín-Requero A,Palomo V
Tue Mar 09 00:00:00 EST 2021
Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS).
Journal of neurochemistry
Vaca G,Martinez-Gonzalez L,Fernandez A,Rojas-Prats E,Porras G,Cuevas EP,Gil C,Martinez A,Martin-Requero Á
Mon Feb 01 00:00:00 EST 2021
Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles.
Pharmaceutics
Rojas-Prats E,Tosat-Bitrián C,Martínez-González L,Nozal V,Pérez DI,Martínez A
Thu Jan 28 00:00:00 EST 2021
Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice.
Acta neuropathologica communications
Ding X,Xiang Z,Qin C,Chen Y,Tian H,Meng L,Xia D,Liu H,Song J,Fu J,Ma M,Wang X
Mon Jan 18 00:00:00 EST 2021
Repetitive Traumatic Brain Injury Is Associated With TDP-43 Alterations, Neurodegeneration, and Glial Activation in Mice.
Journal of neuropathology and experimental neurology
Rajič Bumber J,Pilipović K,Janković T,Dolenec P,Gržeta N,Križ J,Župan G
Fri Jan 01 00:00:00 EST 2021
Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice.
Experimental neurology
Sieverding K,Ulmer J,Bruno C,Satoh T,Tsao W,Freischmidt A,Akira S,Wong PC,Ludolph AC,Danzer KM,Lobsiger CS,Brenner D,Weishaupt JH
Fri Jan 01 00:00:00 EST 2021
Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice.
Experimental neurology
Sieverding K,Ulmer J,Bruno C,Satoh T,Tsao W,Freischmidt A,Akira S,Wong PC,Ludolph AC,Danzer KM,Lobsiger CS,Brenner D,Weishaupt JH
Fri Jan 01 00:00:00 EST 2021
Cytoplasmic mislocalization and mitochondrial colocalization of TDP-43 are common features between normal aged and young mice.
Experimental biology and medicine (Maywood, N.J.)
Termsarasab P,Thammongkolchai T,Gao J,Wang L,Liang J,Wang X
Sun Nov 01 00:00:00 EDT 2020
Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies.
European journal of medicinal chemistry
Gabellieri E,Capotosti F,Molette J,Sreenivasachary N,Mueller A,Berndt M,Schieferstein H,Juergens T,Varisco Y,Oden F,Schmitt-Willich H,Hickman D,Dinkelborg L,Stephens A,Pfeifer A,Kroth H
Thu Oct 15 00:00:00 EDT 2020
Spinal Cord and Motor Neuron TDP-43 Pathology in a Sporadic Inclusion Body Myositis Patient.
Journal of neuropathology and experimental neurology
Cathcart SJ,Greene EP,Powell SZ,Arumanayagam AS,Rivera AL,Tawil R,Appel SH,Cykowski MD
Thu Oct 01 00:00:00 EDT 2020
Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation.
Biomolecules
Fernandes N,Nero L,Lyons SM,Ivanov P,Mittelmeier TM,Bolger TA,Buchan JR
Fri Sep 25 00:00:00 EDT 2020
Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression.
Journal of Alzheimer's disease : JAD
Regalado-Reyes M,Furcila D,Hernández F,Ávila J,DeFelipe J,León-Espinosa G
Wed Sep 09 00:00:00 EDT 2020
Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment.
Science advances
Wang Y,Liu Y,Nham A,Sherbaf A,Quach D,Yahya E,Ranburger D,Bi X,Baudry M
Wed Jul 01 00:00:00 EDT 2020
A clinicopathological study of ALS with L126S mutation in the SOD1 gene presenting with isolated inferior olivary hypertrophy.
Neuropathology : official journal of the Japanese Society of Neuropathology
Hideshima M,Beck G,Yamadera M,Motoyama Y,Ikenaka K,Kakuda K,Tsuda H,Nagano S,Fujimura H,Morii E,Murayama S,Mochizuki H
Wed Apr 01 00:00:00 EDT 2020
Neuronal clusterin expression is associated with cognitive protection in amyotrophic lateral sclerosis.
Neuropathology and applied neurobiology
Gregory JM,Elliott E,McDade K,Bak T,Pal S,Chandran S,Abrahams S,Smith C
Wed Apr 01 00:00:00 EDT 2020
Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment.
Scientific reports
Martínez-González L,Rodríguez-Cueto C,Cabezudo D,Bartolomé F,Andrés-Benito P,Ferrer I,Gil C,Martín-Requero Á,Fernández-Ruiz J,Martínez A,de Lago E
Tue Mar 10 00:00:00 EDT 2020
Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets.
Journal of visualized experiments : JoVE
Sage JM,Hall L,McVey A,Barohn RJ,Statland JM,Jawdat O,Dimachkie MM,Agbas A
Mon Feb 10 00:00:00 EST 2020
Executive, language and fluency dysfunction are markers of localised TDP-43 cerebral pathology in non-demented ALS.
Journal of neurology, neurosurgery, and psychiatry
Gregory JM,McDade K,Bak TH,Pal S,Chandran S,Smith C,Abrahams S
Sat Feb 01 00:00:00 EST 2020
A robust TDP-43 knock-in mouse model of ALS.
Acta neuropathologica communications
Huang SL,Wu LS,Lee M,Chang CW,Cheng WC,Fang YS,Chen YR,Cheng PL,Shen CJ
Tue Jan 21 00:00:00 EST 2020
A robust TDP-43 knock-in mouse model of ALS.
Acta neuropathologica communications
Huang SL,Wu LS,Lee M,Chang CW,Cheng WC,Fang YS,Chen YR,Cheng PL,Shen CJ
Tue Jan 21 00:00:00 EST 2020
Dysregulation of AMPA receptor subunit expression in sporadic ALS post-mortem brain.
The Journal of pathology
Gregory JM,Livesey MR,McDade K,Selvaraj BT,Barton SK,Chandran S,Smith C
Wed Jan 01 00:00:00 EST 2020
Fragile X-associated tremor ataxia syndrome with co-occurrent progressive supranuclear palsy-like neuropathology.
Acta neuropathologica communications
Sacino AN,Prokop S,Walsh MA,Adamson J,Subramony SH,Krans A,Todd PK,Giasson BI,Yachnis AT
Wed Oct 30 00:00:00 EDT 2019
Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis.
Biochemistry
Ng JSW,Hanspal MA,Matharu NS,Barros TP,Esbjörner EK,Wilson MR,Yerbury JJ,Dobson CM,Kumita JR
Tue Oct 01 00:00:00 EDT 2019
Association between TDP-43 and mitochondria in inclusion body myositis.
Laboratory investigation; a journal of technical methods and pathology
Huntley ML,Gao J,Termsarasab P,Wang L,Zeng S,Thammongkolchai T,Liu Y,Cohen ML,Wang X
Mon Jul 01 00:00:00 EDT 2019
Association between TDP-43 and mitochondria in inclusion body myositis.
Laboratory investigation; a journal of technical methods and pathology
Huntley ML,Gao J,Termsarasab P,Wang L,Zeng S,Thammongkolchai T,Liu Y,Cohen ML,Wang X
Mon Jul 01 00:00:00 EDT 2019
Association between TDP-43 and mitochondria in inclusion body myositis.
Laboratory investigation; a journal of technical methods and pathology
Huntley ML,Gao J,Termsarasab P,Wang L,Zeng S,Thammongkolchai T,Liu Y,Cohen ML,Wang X
Mon Jul 01 00:00:00 EDT 2019
Variably protease-sensitive prionopathy mimicking frontotemporal dementia.
Neuropathology : official journal of the Japanese Society of Neuropathology
Aizpurua M,Selvackadunco S,Yull H,Kipps CM,Ironside JW,Bodi I
Mon Apr 01 00:00:00 EDT 2019
Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients.
Molecular neurobiology
Posa D,Martínez-González L,Bartolomé F,Nagaraj S,Porras G,Martínez A,Martín-Requero Á
Mon Apr 01 00:00:00 EDT 2019
Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients.
Molecular neurobiology
Posa D,Martínez-González L,Bartolomé F,Nagaraj S,Porras G,Martínez A,Martín-Requero Á
Mon Apr 01 00:00:00 EDT 2019
Aggregation of the nucleic acid-binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation.
The Journal of biological chemistry
Chen Y,Cohen TJ
Fri Mar 08 00:00:00 EST 2019
Aggregation of the nucleic acid-binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation.
The Journal of biological chemistry
Chen Y,Cohen TJ
Fri Mar 08 00:00:00 EST 2019
Aggregation of the nucleic acid-binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation.
The Journal of biological chemistry
Chen Y,Cohen TJ
Fri Mar 08 00:00:00 EST 2019
Aggregation of the nucleic acid-binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation.
The Journal of biological chemistry
Chen Y,Cohen TJ
Fri Mar 08 00:00:00 EST 2019
Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial.
Muscle & nerve
Statland JM,Moore D,Wang Y,Walsh M,Mozaffar T,Elman L,Nations SP,Mitsumoto H,Fernandes JA,Saperstein D,Hayat G,Herbelin L,Karam C,Katz J,Wilkins HM,Agbas A,Swerdlow RH,Santella RM,Dimachkie MM,Barohn RJ
Fri Feb 01 00:00:00 EST 2019
Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial.
Muscle & nerve
Statland JM,Moore D,Wang Y,Walsh M,Mozaffar T,Elman L,Nations SP,Mitsumoto H,Fernandes JA,Saperstein D,Hayat G,Herbelin L,Karam C,Katz J,Wilkins HM,Agbas A,Swerdlow RH,Santella RM,Dimachkie MM,Barohn RJ
Fri Feb 01 00:00:00 EST 2019
Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis.
Acta neuropathologica communications
Cykowski MD,Powell SZ,Appel JW,Arumanayagam AS,Rivera AL,Appel SH
Fri Apr 13 00:00:00 EDT 2018
Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis.
Acta neuropathologica communications
Cykowski MD,Powell SZ,Appel JW,Arumanayagam AS,Rivera AL,Appel SH
Fri Apr 13 00:00:00 EDT 2018
Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis.
Acta neuropathologica communications
Cykowski MD,Powell SZ,Appel JW,Arumanayagam AS,Rivera AL,Appel SH
Fri Apr 13 00:00:00 EDT 2018
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.
Acta neuropathologica
Henstridge CM,Sideris DI,Carroll E,Rotariu S,Salomonsson S,Tzioras M,McKenzie CA,Smith C,von Arnim CAF,Ludolph AC,Lulé D,Leighton D,Warner J,Cleary E,Newton J,Swingler R,Chandran S,Gillingwater TH,Abrahams S,Spires-Jones TL
Thu Feb 01 00:00:00 EST 2018
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.
Acta neuropathologica
Henstridge CM,Sideris DI,Carroll E,Rotariu S,Salomonsson S,Tzioras M,McKenzie CA,Smith C,von Arnim CAF,Ludolph AC,Lulé D,Leighton D,Warner J,Cleary E,Newton J,Swingler R,Chandran S,Gillingwater TH,Abrahams S,Spires-Jones TL
Thu Feb 01 00:00:00 EST 2018
Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease.
Future science OA
Wilhite R,Sage JM,Bouzid A,Primavera T,Agbas A
Wed Nov 01 00:00:00 EDT 2017
Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease.
Future science OA
Wilhite R,Sage JM,Bouzid A,Primavera T,Agbas A
Wed Nov 01 00:00:00 EDT 2017
Reappraisal of TDP-43 pathology in FTLD-U subtypes.
Acta neuropathologica
Mackenzie IR,Neumann M
Sat Jul 01 00:00:00 EDT 2017
Reappraisal of TDP-43 pathology in FTLD-U subtypes.
Acta neuropathologica
Mackenzie IR,Neumann M
Sat Jul 01 00:00:00 EDT 2017
Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Cykowski MD,Powell SZ,Peterson LE,Appel JW,Rivera AL,Takei H,Chang E,Appel SH
Mon May 01 00:00:00 EDT 2017
Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis.
Journal of neuropathology and experimental neurology
Cykowski MD,Powell SZ,Peterson LE,Appel JW,Rivera AL,Takei H,Chang E,Appel SH
Mon May 01 00:00:00 EDT 2017
In vitro prion-like behaviour of TDP-43 in ALS.
Neurobiology of disease
Smethurst P,Newcombe J,Troakes C,Simone R,Chen YR,Patani R,Sidle K
Thu Dec 01 00:00:00 EST 2016
In vitro prion-like behaviour of TDP-43 in ALS.
Neurobiology of disease
Smethurst P,Newcombe J,Troakes C,Simone R,Chen YR,Patani R,Sidle K
Thu Dec 01 00:00:00 EST 2016
In vitro prion-like behaviour of TDP-43 in ALS.
Neurobiology of disease
Smethurst P,Newcombe J,Troakes C,Simone R,Chen YR,Patani R,Sidle K
Thu Dec 01 00:00:00 EST 2016
In vitro prion-like behaviour of TDP-43 in ALS.
Neurobiology of disease
Smethurst P,Newcombe J,Troakes C,Simone R,Chen YR,Patani R,Sidle K
Thu Dec 01 00:00:00 EST 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 EDT 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 EDT 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 EDT 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 EDT 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 EDT 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 EDT 2016
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.
Molecular neurodegeneration
Alquezar C,Salado IG,de la Encarnación A,Pérez DI,Moreno F,Gil C,de Munain AL,Martínez A,Martín-Requero Á
Sat Apr 30 00:00:00 EDT 2016
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.
Molecular neurodegeneration
Alquezar C,Salado IG,de la Encarnación A,Pérez DI,Moreno F,Gil C,de Munain AL,Martínez A,Martín-Requero Á
Sat Apr 30 00:00:00 EDT 2016
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.
Molecular neurodegeneration
Alquezar C,Salado IG,de la Encarnación A,Pérez DI,Moreno F,Gil C,de Munain AL,Martínez A,Martín-Requero Á
Sat Apr 30 00:00:00 EDT 2016
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.
Molecular neurodegeneration
Alquezar C,Salado IG,de la Encarnación A,Pérez DI,Moreno F,Gil C,de Munain AL,Martínez A,Martín-Requero Á
Sat Apr 30 00:00:00 EDT 2016
ALS-FUS pathology revisited: singleton FUS mutations and an unusual case with both a FUS and TARDBP mutation.
Acta neuropathologica communications
King A,Troakes C,Smith B,Nolan M,Curran O,Vance C,Shaw CE,Al-Sarraj S
Fri Oct 09 00:00:00 EDT 2015
An autopsy case of familial amyotrophic lateral sclerosis with a TARDBP Q343R mutation.
Neuropathology : official journal of the Japanese Society of Neuropathology
Okamoto K,Fujita Y,Hoshino E,Tamura Y,Fukuda T,Hasegawa M,Takatama M
Thu Oct 01 00:00:00 EDT 2015
An autopsy case of familial amyotrophic lateral sclerosis with a TARDBP Q343R mutation.
Neuropathology : official journal of the Japanese Society of Neuropathology
Okamoto K,Fujita Y,Hoshino E,Tamura Y,Fukuda T,Hasegawa M,Takatama M
Thu Oct 01 00:00:00 EDT 2015
An autopsy case of familial amyotrophic lateral sclerosis with a TARDBP Q343R mutation.
Neuropathology : official journal of the Japanese Society of Neuropathology
Okamoto K,Fujita Y,Hoshino E,Tamura Y,Fukuda T,Hasegawa M,Takatama M
Thu Oct 01 00:00:00 EDT 2015
An autopsy case of familial amyotrophic lateral sclerosis with a TARDBP Q343R mutation.
Neuropathology : official journal of the Japanese Society of Neuropathology
Okamoto K,Fujita Y,Hoshino E,Tamura Y,Fukuda T,Hasegawa M,Takatama M
Thu Oct 01 00:00:00 EDT 2015
PABPN1 suppresses TDP-43 toxicity in ALS disease models.
Human molecular genetics
Chou CC,Alexeeva OM,Yamada S,Pribadi A,Zhang Y,Mo B,Williams KR,Zarnescu DC,Rossoll W
Tue Sep 15 00:00:00 EDT 2015
PABPN1 suppresses TDP-43 toxicity in ALS disease models.
Human molecular genetics
Chou CC,Alexeeva OM,Yamada S,Pribadi A,Zhang Y,Mo B,Williams KR,Zarnescu DC,Rossoll W
Tue Sep 15 00:00:00 EDT 2015
Adult polyglucosan body disease with GBE1 haploinsufficiency and concomitant frontotemporal lobar degeneration.
Neuropathology and applied neurobiology
Bit-Ivan EN,Lee KH,Gitelman D,Weintraub S,Mesulam M,Rademakers R,Isaacs AM,Hatanpaa KJ,White CL,Mao Q,Akman O,DiMauro S,Bigio EH
Wed Oct 01 00:00:00 EDT 2014
β-N-methylamino-L-alanine induces changes in both GSK3 and TDP-43 in human neuroblastoma.
The Journal of toxicological sciences
Muñoz-Saez E,de Munck E,Arahuetes RM,Solas MT,Martínez AM,Miguel BG
Wed Oct 23 00:00:00 EDT 2013
Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis.
Acta neuropathologica
Dobson-Stone C,Luty AA,Thompson EM,Blumbergs P,Brooks WS,Short CL,Field CD,Panegyres PK,Hecker J,Solski JA,Blair IP,Fullerton JM,Halliday GM,Schofield PR,Kwok JB
Mon Apr 01 00:00:00 EDT 2013
Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis.
Acta neuropathologica
Dobson-Stone C,Luty AA,Thompson EM,Blumbergs P,Brooks WS,Short CL,Field CD,Panegyres PK,Hecker J,Solski JA,Blair IP,Fullerton JM,Halliday GM,Schofield PR,Kwok JB
Mon Apr 01 00:00:00 EDT 2013
An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pelletier S,Gingras S,Howell S,Vogel P,Ihle JN
Wed Nov 21 00:00:00 EST 2012
An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pelletier S,Gingras S,Howell S,Vogel P,Ihle JN
Wed Nov 21 00:00:00 EST 2012
