This antibody is predicted to react with mouse and rat based on sequence homology.
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
Protein Aliases: 2310008J16Rik; 2810405N18Rik; anthrax toxin receptor; Anthrax toxin receptor 1; FLJ10601; FLJ11298; FLJ21776; Tem-8; Tumor endothelial marker 8
Gene Aliases: ANTXR1; ATR; GAPO; TEM8
UniProt ID: (Human) Q9H6X2
Entrez Gene ID: (Human) 84168
Molecular Function: cell adhesion molecule