Invitrogen

Phospho-TYK2 (Tyr1054) Polyclonal Antibody

View all (18) TYK2 antibodies

Questions & Answers

Questions & Answers

Product Image Gallery

Phospho-TYK2 (Tyr1054) Antibody in Western Blot (WB) — Western blot analysis of extracts from HT29 cells, untreated (Lane 1) or treated with Anisomycin (Lane 2), using TYK2 (pTyr1054) polyclonal antibody (Product # PA5-37762).

Product Details

PA5-37762

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Peptide sequence around phosphorylation site of tyrosine 1054 (H-E-Y(p)-Y-R) derived from Human TYK2. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS, pH 7.4, with 50% glycerol, 150mM NaCl
Contains	0.02% sodium azide
Storage conditions	-20°C
RRID	AB_2554370

Product Specific Information

A suggested positive control for Western blot is HT29 cells.

Target Information

TYK2 is a member of the Janus kinases (JAKs) protein family. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

An Essential Role for Perforin-2 in Type I IFN Signaling.

Journal of immunology (Baltimore, Md. : 1950)

McCormack R,Hunte R,Podack ER,Plano GV,Shembade N

PA5-37762 was used in Western Blot to study the initial complex formation occurring during type-1 IFN signaling during the host-pathogen response..

Wed Apr 15 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; mKIAA4116; Non-receptor tyrosine-protein kinase TYK2; tyrosine kinase TYK2

Gene Aliases: IMD35; JTK1; TYK2

UniProt ID: (Human) P29597, (Mouse) Q9R117

Entrez Gene ID: (Human) 7297, (Rat) 100361294, (Mouse) 54721

transmembrane receptor protein tyrosine kinase signaling pathway cell migration cell differentiation intracellular signal transduction peptidyl-tyrosine autophosphorylation regulation of cell proliferation innate immune response protein phosphorylation type I interferon signaling pathway regulation of type I interferon-mediated signaling pathway phosphorylation peptidyl-tyrosine phosphorylation

Process(es)

protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity growth hormone receptor binding protein binding ATP binding type 1 angiotensin receptor binding hormone receptor binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups