Invitrogen

Phospho-TYK2 (Tyr433) Polyclonal Antibody

View all (18) TYK2 antibodies

Questions & Answers

Questions & Answers

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Phospho-TYK2 (Tyr433) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of paraffin-embedded Phospho-TYK2 (Tyr433) in human kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-TYK2 (Tyr433) polyclonal antibody (Product # PA5-105556) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.

Phospho-TYK2 (Tyr433) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of paraffin-embedded Phospho-TYK2 (Tyr433) in human liver tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-TYK2 (Tyr433) polyclonal antibody (Product # PA5-105556) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.

Phospho-TYK2 (Tyr433) Antibody in Western Blot (WB) — Western blot analysis of Phospho-TYK2 (Tyr433) in 293 treated with heat-shock (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-TYK2 (Tyr433) polyclonal antibody (Product # PA5-105556).

Product Details

PA5-105556

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:200	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	A synthesized peptide derived from human TYK2 around the phosphorylation site of Tyr433. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	sequential chromatography
Storage buffer	PBS, pH 7.4, with 50% glycerol, 150mM NaCl
Contains	0.02% sodium azide
Storage conditions	-20°C
RRID	AB_2816984

Target Information

TYK2 is a member of the Janus kinases (JAKs) protein family. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; mKIAA4116; Non-receptor tyrosine-protein kinase TYK2; tyrosine kinase TYK2

Gene Aliases: IMD35; JTK1; TYK2

UniProt ID: (Human) P29597, (Mouse) Q9R117

Entrez Gene ID: (Human) 7297, (Mouse) 54721

protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway cell migration cell differentiation intracellular signal transduction peptidyl-tyrosine autophosphorylation regulation of cell proliferation innate immune response type I interferon signaling pathway regulation of type I interferon-mediated signaling pathway phosphorylation peptidyl-tyrosine phosphorylation

Process(es)

protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity growth hormone receptor binding protein binding ATP binding type 1 angiotensin receptor binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups hormone receptor binding