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Invitrogen
Phospho-TYK2 (Tyr433) Polyclonal Antibody
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FIGURE: 1 / 3
Phospho-TYK2 (Tyr433) Antibody (PA5-105556) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-TYK2 (Tyr433) in human kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-TYK2 (Tyr433) polyclonal antibody (Product # PA5-105556) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-105556
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TYK2(Accession P29597), corresponding to amino acid residues around phosphorylated Tyr433.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2816984
Product Specific Information
Antibody detects endogenous levels of TYK2 only when phosphorylated at Tyr433.
Target Information
Tyrosine Kinase 2 (TYK2) a member of the JAK kinase family, plays both structural and catalytic roles in type I interferon (IFN) signaling. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; mKIAA4116; Non-receptor tyrosine-protein kinase TYK2; tyrosine kinase TYK2
Gene Aliases: IMD35; JTK1; TYK2
UniProt ID: (Human) P29597, (Mouse) Q9R117
Entrez Gene ID: (Human) 7297, (Mouse) 54721
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
growth hormone receptor binding
protein binding
ATP binding
type 1 angiotensin receptor binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
hormone receptor binding
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
cell migration
cell differentiation
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
phosphorylation
peptidyl-tyrosine phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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