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7TM Antibodies
Phospho-Tachykinin Receptor 1 (Thr356, Thr357) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-Tachykinin Receptor 1 (Thr356, Thr357) Antibody (7TM0360C) in WB
Agonist-induced Threonine356/Threonine357 phosphorylation of NK1 Receptor. Upper panel, HEK293 cells stably expressing the NK1-Receptor (NK1) were either not exposed or exposed to 1 µM of specific NK1-Receptor Agonist Substance P for 30 minutes. Cells were lysed and immunoblotted with the anti-pT356/pT357-NK1 antibody (7TM0360C) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed with the ... View More
Product Details
7TM0360C
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human NK1 around the phosphorylation site Thr356/Thr357.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: NK-1 receptor; NK-1R; SPR; Substance-P receptor; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
Gene Aliases: NK1R; NKIR; SPR; TAC1R; TACR1
UniProt ID: (Human) P25103
Entrez Gene ID: (Human) 6869
aggressive behavior
acute inflammatory response
positive regulation of leukocyte migration
angiotensin-mediated drinking behavior
inflammatory response
cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
tachykinin receptor signaling pathway
chemical synaptic transmission
long-term memory
associative learning
response to heat
detection of abiotic stimulus
response to ozone
positive regulation of epithelial cell migration
response to auditory stimulus
regulation of smooth muscle cell migration
sensory perception of pain
positive regulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, GABAergic
response to estradiol
response to progesterone
response to nicotine
operant conditioning
positive regulation of renal sodium excretion
sperm ejaculation
eating behavior
positive regulation of vascular permeability
response to morphine
response to ethanol
positive regulation of action potential
positive regulation of blood pressure
positive regulation of ossification
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
positive regulation of saliva secretion
positive regulation of hormone secretion
behavioral response to pain
regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of epithelial cell proliferation
positive regulation of stress fiber assembly
response to electrical stimulus
smooth muscle contraction involved in micturition
positive regulation of uterine smooth muscle contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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