|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide corresponding to residues surrounding pTyr490 of human TrkA|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
It is not recommended to aliquot this antibody.
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: gp140trk; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; trk; Trk-A; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A
Gene Aliases: C80751; MTC; NTRK1; p140-TrkA; Tkr; TRK; Trk-A; TRK1; TRKA
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