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Western blot analysis of Phospho-TrkA pTyr674/675 /TrkB pTyr706/707 in extracts from NIH/3T3 cells transfected with TrkA or TrkB, and treated with NGF or BDNF, using Phospho-TrkA pTyr674/675 /TrkB pTyr706/707 monoclonal antibody (Product # MA5-14927) (upper) or pooled TrkA/TrkB Antibodies (lower).
|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide corresponding to residues surrounding pTyr674/675 of human TrkA|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Contains||<0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
It is not recommended to aliquot this antibody.
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; gp140trk; GP145-TrkB/GP95-TrkB; high affinity nerve growth factor receptor; neural receptor protein-tyrosine kinase (trkB); neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; Oncogene TRK; p140-TrkA; slow nerve growth factor receptor; trk; trk-A; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; trkB tyrosine kinase; tropomyosin-related kinase A; tropomyosin-related kinase B; tyrosine kinase receptor A; tyrosine kinase receptor B
C80751; GP145-TrkB; GP145-TrkB/GP95-TrkB; MTC; NTRK1; NTRK2; p140-TrkA; RATTRKB1; Tkr; Tkrb; TRK; Trk-A; trk-B; TRK1; TRKA; TRKB; TRKB1