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Phospho-Tyk2 (Tyr1054, Tyr1055) Polyclonal Antibody

View all (18) TYK2 antibodies

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Phospho-Tyk2 (Tyr1054, Tyr1055) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Paraformaldehyde-fixed, paraffin embedded mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with Tyk2(Tyr1054 + Tyr1055) Polyclonal Antibody, Unconjugated (bs-3437R) at 1:400 overnight at 4°C, DAB staining.

Phospho-Tyk2 (Tyr1054, Tyr1055) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Paraformaldehyde-fixed, paraffin embedded rat brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with Tyk2(Tyr1054 + Tyr1055) Polyclonal Antibody, Unconjugated (bs-3437R) at 1:400 overnight at 4°C, DAB staining.

Phospho-Tyk2 (Tyr1054, Tyr1055) Antibody in Western Blot (WB) — A549 lysates probed with Phospho-Tyk2(Tyr1054 + Tyr1055) Polyclonal Antibody, Unconjugated (bs-3437R) at 1:500 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37°C.

Product Details

BS-3437R

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500	-
Immunohistochemistry (Paraffin) (IHC (P))	1:400	-
Immunohistochemistry (Frozen) (IHC (F))	1:100-1:500	-
Immunocytochemistry (ICC/IF)	1:50-1:200	-
ELISA (ELISA)	1:500-1:1,000	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	KLH conjugated synthetic phosphopeptide derived from human Tyk2 around the phosphorylation site of Tyr1054/1055. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein A
Storage buffer	PBS with 1% BSA, 50% glycerol
Contains	0.09% sodium azide
Storage conditions	-20°C

Target Information

TYK2 is a member of the Janus kinases (JAKs) protein family. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; mKIAA4116; Non-receptor tyrosine-protein kinase TYK2; tyrosine kinase TYK2

Gene Aliases: IMD35; JTK1; TYK2

UniProt ID: (Human) P29597, (Mouse) Q9R117

Entrez Gene ID: (Human) 7297, (Rat) 100361294, (Mouse) 54721

transmembrane receptor protein tyrosine kinase signaling pathway cell migration cell differentiation intracellular signal transduction peptidyl-tyrosine autophosphorylation regulation of cell proliferation innate immune response protein phosphorylation type I interferon signaling pathway regulation of type I interferon-mediated signaling pathway phosphorylation peptidyl-tyrosine phosphorylation

Process(es)

protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity growth hormone receptor binding protein binding ATP binding type 1 angiotensin receptor binding hormone receptor binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups