The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
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Protein Aliases: Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; Vav proto-oncogene
Gene Aliases: VAV; VAV1
UniProt ID: (Human) P15498
Entrez Gene ID: (Human) 7409