Positive Control: Jurkat (serum starvation for 15 min), Jurkat (serum starvation for 15 min, then 0.13 µg/mL anti-T-cell receptor antibody (clone 305) treatment for 5 min)
Predicted Reactivity: Rat (100%), Pig (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
VAV1 gene was originally identified on the basis of its oncogenic activation during the course of gene transfer assays. The major translational product of the Vav proto-oncogene has been identified as a protein containing an array of structural motifs. Contained within its amino terminus are a helix-loop-helix domain and a leucine zipper motif similar to that of Myc family proteins deletion of this region of p95Vav causes its oncogenic activation. In addition, p95Vav contains an SH2 domain, which could indicate its role as a substrate for tyrosine kinases. Expression of p95Vav is limited exclusively to cells of hematopoietic origin, including those of the erythroid, lymphoid and myeloid lineages.
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Protein Aliases: Proto-oncogene vav; vav 1 guanine nucleotide exchange factor; vav 1 oncogene
Gene Aliases: VAV; VAV1
UniProt ID: (Human) P15498
Entrez Gene ID: (Human) 7409