|Western Blot (WB)||Assay Dependent|
|Miscellaneous PubMed (MISC)||See 2 publications below|
|Immunofluorescence (IF)||See 3 publications below|
|Western Blot (WB)||See 3 publications below|
|Tested Species reactivity||Human, Non-human primate|
|Published species reactivity||Tag , Hamster , Mouse Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human VE-cadherin that contains tyrosine 731. This sequence is conserved in chimpanzee.|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.3, with 1mg/ml BSA, 50% glycerol|
|Contains||0.05% sodium azide|
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 7B4 antigen; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144; CD144 antigen; CDH5; endothelial-specific cadherin; Vascular endothelial cadherin; VE-cadherin
Gene Aliases: 7B4; CD144; CDH5
UniProt ID: (Human) P33151
Entrez Gene ID: (Human) 1003
Molecular Function: cadherin
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