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Vav3 [pY173] phosphospecific antibody. Cos7 cells over-expressing murine Vav3 were serum starved and left untreated (1) or treated (2-5) with EGF were incubated with Vav3 [pY173] antibody following prior incubation with: no peptide (1, 2), the non-phospho immunogen (3), a generic [pY] peptide (4), or, the phosphopeptide immunogen (5). Data demonstrate antibody specificity.
|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human Vav3 that contains tyrosine 173.|
|Storage buffer||Dulbecco's PBS, pH 7.3, with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.1-1.0 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Mouse||Not Cited||Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.||Zou W,Kitaura H,Reeve J,Long F,Tybulewicz VL,Shattil SJ,Ginsberg MH,Ross FP,Teitelbaum SL||The Journal of cell biology (176:877)||2007|
FLJ40431; guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3; VAV3
A530094I06Rik; AA986410; Idd18.1; Vav3