WNK is a serine/threonine kinase that plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Also, acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis, the distal nephron. Mutations in the WNK gene result in Pseudohypaldosteronism and Neuropathy.
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Protein Aliases: Erythrocyte 65 kDa protein; hWNK1; KDP; Kinase deficient protein; p65; PRKWNK1 PROTEIN KINASE LYSINE-DEFICIENT 1; prostate-derived sterile 20-like kinase; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; protein phosphatase 1, regulatory subunit 167; Serine/threonine-protein kinase WNK1; serine/threonine-protein kinase WNK1 1; serine/threonine-protein kinase WNK1 2; WNK lysine deficient protein kinase 1; WNK lysine deficient protein kinase 1 isoform
Gene Aliases: 6430573H23Rik; EG406236; HSAN2; HSN2; KDP; KIAA0344; mKIAA0344; p65; PPP1R167; PRKWNK1; PSK; WNK1