This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with Monkey, Bovine, Cat, Pig.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Catenin Beta-1 (CTNB1) is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, CTNB1 forms a complex with AXIN1, AXIN2, APC, CSNK1A1, and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. It is also involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. CTNB1 acts as a negative regulator of centrosome cohesion. Mutations in the gene can results in multiple diseases including colorectal cancer, pilomatrixoma, medulloblastoma, ovarian cancer, mesothelioma, mental retardation, and vitreoretinopahty.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta-catenin; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin beta-1; CTNNB; CTNNB1
Gene Aliases: armadillo; CTNNB; CTNNB1; MRD19; OK/SW-cl.35; PRO2286
UniProt ID: (Human) P35222
Entrez Gene ID: (Human) 1499