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Immunohistochemical analysis of Phospho-eIF2-alpha pSer51 in paraffin-embedded human lung carcinoma using a Phospho-eIF2-alpha pSer51 monoclonal antibody (Product # MA5-15133) in the presence of control peptide (left) or Phospho-eIF2alpha (Ser51) blocking peptide (right).
|Tested species reactivity||Fruit fly, Human, Mouse, Primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide corresponding to residues surrounding pSer51 of human eIF2alpha|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Contains||<0.02% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
It is not recommended to aliquot this antibody.
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CG9946-PA; CG9946-PB; eIF-2-alpha; EIF-2A; EIF-2alpha; eIF-2alpha-PA; eIF-2alpha-PB; eukaryotic initiation factor 2alpha; eukaryotic translation initiation factor 2; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; eukaryotic translation initiation factor 2A; eukaryotic translation initiation factor 2alpha; minute (1) 14C; OTTHUMP00000218025
0910001O23Rik; 2410026C18Rik; 35kDa; CG9946; deIF2alpha; Dmel\CG9946; Dmel_CG9946; EIF-2; eIF-2 a; eIF-2 alpha; EIF-2A; EIF-2alpha; eIF-2alphaeIF-2alpha; EIF2; eIF2 alpha; eIF2-alpha; EIF2A; Eif2alpha; EIF2S1; elF2alpha; IF2A_DROME; l(1)14Cf; l(1)19-153; M(1)14C; M(1)19-153; M(1)8e3-10