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The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human mTOR that contains serine 2448. The sequence is conserved in human, mouse and rat.
Antigen affinity chromatography
Dulbecco's PBS, pH 7.3, with 1mg/ml BSA, 50% glycerol
0.05% sodium azide
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays a key role in cell growth, cell proliferation, and protein synthesis. mTOR mediates phosphoinositide 3-kinase and Akt/PKB signaling, resulting in phosphorylation of 4EBP1, and initiation of mRNA translation. A second pathway involves regulation of ribosomal S6 kinase, which affects ribosome biogenesis and translation elongation.
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Protein Aliases: angiopoietin-like factor CDT6; EC 18.104.22.168; FK506 binding protein 12-rapamycin associated protein; FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein (FRAP); FKBP-rapamycin-associated protein FRAP; FKBP12-rapamycin complex-associated protein; FKBP12-rapamycin complex-associated protein 1; FRAP1; FRAP2; m-TOR; Mammalian Target Of Rapamycin; Mechanistic Target Of Rapamycin; mechanistic target of rapamycin (serine/threonine kinase); MTOR; RAFT1; Rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; Rapamycin Target Protein; Rapamycin target protein 1; RAPT1; Serine/Threonine-Protein Kinase MTOR