|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||1-3 µg/ml|
|Western Blot (WB)||See 4 publications below|
|Immunofluorescence (IF)||See 1 publications below|
|Immunohistochemistry (IHC)||See 1 publications below|
|Immunoprecipitation (IP)||See 1 publications below|
|Published species||Human, Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Synthetic peptide encompassing the phosphorylated Thr187 residue of human p27|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
p27Kip1 is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDKN1B; CDN1B; Cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor p27; KIP1; p27Kip1
Gene Aliases: CDKN1B; CDKN4; KIP1; MEN1B; MEN4; P27KIP1
UniProt ID: (Human) P46527
Entrez Gene ID: (Human) 1027
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