Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
p38 Mitogen-activated protein kinase (MAPK) belongs to the mitogen-activated protein kinase family, which responds to stress stimuli. The p38 MAPK subfamily plays an important role in cytokine production and the stress response. Members are activated by UV irradiation, heat shock, high osmotic stress, protein synthesis inhibitors, lipopolysaccharides, proinflammatory cytokines (e.g., IL-1 and TNF-alpha) and certain mitogens. There are four p38 kinases ( alpha, beta, lambda, and delta), with p38 alpha being well characterized, and expressed in most cell types. Additional functions for p38 MAPK include inhibition of cell cycle progression, development, and differentiation. An important target of p38 MAPK is the tumor suppressor protein p53, whose activation is positively regulated by p38. MKK3, MKK6 and SEK phosphorylate p38 MAPK at threonine 180 and tyrosine 182. Phosphorylation of these residues activates p38 MAPK, which in turn activates and phosphorylates ATF1, ATF2 and ATF6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CSAID binding protein; CSAID-binding protein; Csaids binding protein; CSBP; CSBP1; CSBP2; CSPB1; Cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug-binding protein; EXIP; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAP kinase p38alpha; MAX-interacting protein 2; Mitogen-activated protein kinase 14; mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase p38alpha; Mxi2; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38ALPHA; p38alpha Exip; PRKM14; PRKM15; RK; SAPK2A; stress-activated protein kinase 2A
Gene Aliases: CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A
Entrez Gene ID: (Human) 1432