Antigen Affinity Purified from Pooled Serum
The p70 S6 kinase (p70 Ribosomal Protein S6 Kinase, p70S6K) is a 70 kDa member of the ribosomal S6 kinase (RSK) family of serine/threonine kinases. p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.
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Protein Aliases: CG10539-PA; CG10539-PB; Dp70s6k; dS6 kinase; EC 220.127.116.11; kinase p70S6K; KS6B1; p70 p70-S6K; p70 ribosomal S6 kinase; p70 S6 kinase; p70 S6 kinase 1; p70S6 kinase; p70S6K kinase; p70S6K-alpha; p80-S6K 1; p85 p85S6K; protein kinase-like 64F; ribosomal S6 protein kinase; RPS6-p70-protein kinase; S6 kinase; S6-kinase; S6K kinase; S6k-PA; S6k-PB; S6kinase
Gene Aliases: 10539; 7-10; 7084; CG10539; d-S6K; Dmel\CG10539; Dmel_CG10539; Dp70[s6k]; Dp70S6k; dps6k; DS6K; dS6K1; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70/S6K; p70[S6 kinase]; p70[S6K]; p70[S6kinase]; p70S6K; Pk64F; Pk?6; S6 K; S6K; S6K1; s6k11; S6k|S6K
Entrez Gene ID: (Fruit fly) 38654
Molecular Function: annexin calcium-binding protein calmodulin intracellular calcium-sensing protein kinase non-receptor serine/threonine protein kinase protein kinase transfer/carrier protein transferase