Invitrogen

Phospho-p73 (Tyr99) Polyclonal Antibody

View all (39) p73 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-104698

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TP73(Accession O15350), corresponding to amino acid residues around phosphorylated Tyr99.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2816171

Product Specific Information

Antibody detects endogenous levels of p73 only when phosphorylated at Tyrosine 99.

Target Information

P73 (TP73) participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; RP23-254N4.10; transformation related protein 73; Tumor protein p73

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Gene Aliases: deltaNp73; P73; TAp73; TP73; Trp73

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UniProt ID: (Human) O15350, (Mouse) Q9JJP2

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Entrez Gene ID: (Human) 7161, (Rat) 362675, (Mouse) 22062

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding p53 binding chromatin binding damaged DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein kinase binding identical protein binding transcription regulatory region DNA binding metal ion binding DNA binding double-stranded DNA binding sequence-specific DNA binding P53-like transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity kidney development mismatch repair transcription from RNA polymerase II promoter cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle arrest regulation of mitotic cell cycle intrinsic apoptotic signaling pathway in response to DNA damage response to X-ray response to organonitrogen compound response to gamma radiation regulation of gene expression viral process mitotic G1 DNA damage checkpoint cellular response to UV response to drug intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process negative regulation of JUN kinase activity negative regulation of neuron apoptotic process negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of oligodendrocyte differentiation protein tetramerization negative regulation of cardiac muscle cell proliferation positive regulation of cell cycle arrest positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator release of cytochrome c from mitochondria inflammatory response post-embryonic development hippocampus development forebrain development cerebrospinal fluid secretion positive regulation of apoptotic process regulation of neuron apoptotic process positive regulation of cell size digestive tract morphogenesis neuron development positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process cell cycle
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