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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Synthetic peptide derived from the internal region of the human Pim-1|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ChIP assay (ChIP)||1:100|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
42-4800 has been successfully used in ChIP analysis of PIM1 in human J9.2 J-lat T lymphocytes.
PIM1, which belongs to the Serine/Threonine protein kinase family, is thought to play a role in signal transduction in blood cells. The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer. It may affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. PIM1 is expressed primarily in cells of the hematopoietic and germ line lineages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells.
39-4600 was used in western blot to show that subcellular targeting bolsters the cardioprotective effects of Pim1 in primary human cardiac progenitor cells
|Samse K,Emathinger J,Hariharan N,Quijada P,Ilves K,Völkers M,Ormachea L,De La Torre A,Orogo AM,Alvarez R,Din S,Mohsin S,Monsanto M,Fischer KM,Dembitsky WP,Gustafsson ÅB,Sussman MA||The Journal of biological chemistry (290:13935)||2015|
Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1); proto-oncogene serine/threonine-protein kinase pim-1