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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Purified human Placental Alkaline Phosphatase (PLAP)|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:40-1:80|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-14064 targets Placental Alk Phosphatase in immunohostochemistry (Paraffin) applications and shows reactivity with Human samples. Staining of formalin-fixed tissue sections requires treating the tissue sections in boiling 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at room temperature for 20 minutes.
The MA5-14064 immunogen is purified human Placental Alkaline Phosphatase (PLAP).
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Ovarian microcystic stromal tumor: A novel extracolonic tumor in familial adenomatous polyposis.
MA5-14064 was used in immunohistochemistry - paraffin section to describe a 40-year-old female patient with ovarian microcystic stromal tumor and familial adenomatous polyposis
|Lee SH,Koh YW,Roh HJ,Cha HJ,Kwon YS||Genes, chromosomes & cancer (54:353)||2015|
Recurrent seminomas: clinical features and biologic implications.
MA5-14064 was used in immunohistochemistry to study the clinical characteristics and treatment profile of recurrent seminomas
|Som A,Zhu R,Guo CC,Efstathiou E,Xiao L,Pisters LL,Matin A,Tu SM||Urologic oncology (30:494)||2012|
alkaline phosphatase; alkaline phosphatase Regan isozyme; alkaline phosphomonoesterase; glycerophosphatase; placental alkaline phosphatase 1; placental type; PLAP-1; Regan isozyme
ALP; ALPP; PALP; PLAP; PLAP-1