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Plasma Kallikrein Antibody (PA5-92392) in IHC (P)
Immunohistochemistry analysis of Plasma Kallikrein in paraffin-embedded human placenta. Samples were incubated with Plasma Kallikrein Polyclonal antibody (Product # PA5-92392) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-92392
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human KLKB1 (NP_0008832)
Conjugate
Form
Liquid
Concentration
2.16 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2806472
Product Specific Information
Immunogen sequence: GCLTQLYENA FFRGGDVASM YTPNAQYCQM RCTFHPRCLL FSFLPASSIN DMEKRFGCFL KDSVTGTLPK VHRTGAVSGH SLKQCGHQIS ACHRDIYKGV DMRGVNFNVS KVSSVEECQK RCTSNIRCQF FSYATQTFHK AEYRNNCLLK YSPGGTPTAI KVLSNVESGF SLKPCALSEI GCHMNIFQHL AFSDVDVARV LTPDAFVCRT ICTYHPNCLF FTFYTNVWKI ESQRNVCLLK TSESGTPSSS TPQENTISGY SLLTCKRTLP EPCHSKIYPG V; Positive Samples: Mouse liver, Mouse intestine, Mouse brain
Target Information
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen, prostate specific; EC 3.4.21.34; Fletcher factor; kallikrein 3, plasma; kallikrein B plasma; kallikrein B, plasma (Fletcher factor) 1; Kininogenin; PKK; Plasma kallikrein; Plasma prekallikrein
Gene Aliases: APS; Kal-3; Kal3; Kalp1; KALP15; KLK3; KLKB1; Pk; PKK; PKKD; PPK; PSA
UniProt ID: (Human) P03952, (Mouse) P26262
Entrez Gene ID: (Human) 3818, (Rat) 25048, (Mouse) 16621
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