In direct ELISAs, less than 1% cross-reactivity with recombinant mouse (rm) Plexin A2 and rmPlexin A3 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. [UniProt]
Protein Aliases: Plex 1; plexin 1; plexin-1; Plexin-A1
Gene Aliases: 2600013D04Rik; Kiaa4053; mKIAA4053; NOV; PlexA1; Plxn1; Plxna1
UniProt ID: (Mouse) P70206
Entrez Gene ID: (Mouse) 18844