Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional receptor for chemorepellent semaphorins. The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger redistribution and depolymerization of actin filaments resulting in cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A.
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Protein Aliases: NOV; NOVP; plexin 1; PLEXIN-A1; PLXN1; Semaphorin receptor NOV
Gene Aliases: NOV; NOVP; PLEXIN-A1; PLXN1; PLXNA1
UniProt ID: (Human) Q9UIW2
Entrez Gene ID: (Human) 5361