Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional receptor for chemorepellent semaphorins. The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger redistribution and depolymerization of actin filaments resulting in cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Plex 1; plexin 1; plexin A1; plexin-1; Plexin-A1; Semaphorin receptor NOV
Gene Aliases: 2600013D04Rik; Kiaa4053; mKIAA4053; NOV; NOVP; PlexA1; PLEXIN-A1; PLXN1; PLXNA1; RGD1560871